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Genomics

A collection of 27 posts

A wormy discovery becomes a knockout laboratory technique

Historical Paper Review

A wormy discovery becomes a knockout laboratory technique

One of the best ways to figure out what a gene does is to get rid of it and see what happens.

Pangenomes are here to bring equity to genomics

Pangenomes are here to bring equity to genomics

Reference genomes: what they are and why the next big thing in genomics is the human pangenome.

Why short-read sequencing can't ever get us a 'whole genome'

Why short-read sequencing can't ever get us a 'whole genome'

Short-reads miss things, or: How I learned to stop worrying and love the long-read.

Frederick Sanger sequenced the first DNA genome, he didn't use 'Sanger Sequencing' to do it

Genomic Sequencing

Frederick Sanger sequenced the first DNA genome, he didn't use 'Sanger Sequencing' to do it

Frederick Sanger invented a famous DNA sequencing method. It's not the one pictured below (which he also invented).

Bridge RNAs are here to take CRISPR's crown

Bridge RNAs are here to take CRISPR's crown

Move over CRISPR, bridge RNAs are here to make the precision genome edits that you can't.

Metabolomics: Hype or Heroine?

Metabolomics: Hype or Heroine?

How does the promise of metabolomics stack up against our current reality? It’s complicated.

Make way for the METABOLOME ..ome ..ome.. ome!!!

Make way for the METABOLOME ..ome ..ome.. ome!!!

What's the biggest Ome of them all?

The microbiome and metagenome, what's the difference?

The microbiome and metagenome, what's the difference?

Depends who you ask.

Genetic Determinism: What it is and how we can avoid it with multi-omics

Genetic Determinism: What it is and how we can avoid it with multi-omics

One thing we constantly battle in genomics is, “What does it all mean?”

Barbara McClintock discovered a little thing called the transposable element in 1950

Barbara McClintock discovered a little thing called the transposable element in 1950

While everyone else was distracted by the structure of DNA, Barbara McClintock was discovering a little thing called the transposable element.

The evolutionary history of coffee is probably more complicated than you think

The evolutionary history of coffee is probably more complicated than you think

That dark and delicious brew billowing clouds of irresistible coffee incense next to you is most likely the product of Coffea arabica.

Pacific Biosciences drops nearly 50% after a bad earnings report and a mind-boggling update to their product roadmap

Paid-members only

Genomics Featured

Pacific Biosciences drops nearly 50% after a bad earnings report and a mind-boggling update to their product roadmap

Quest Diagnostics has made some moves in an attempt to become a major player in high throughput genomics

Paid-members only

Genomic Sequencing Featured

Quest Diagnostics has made some moves in an attempt to become a major player in high throughput genomics

Epigenome editors are coming for cholesterol (and other diseases)!

Epigenome editors are coming for cholesterol (and other diseases)!

Ever heard of an ‘epigenome editor?’ Well, buckle up, because they could be the source of a long-term cure for high cholesterol!

The story of how apes (and humans) lost their tails!

Evolution Featured

The story of how apes (and humans) lost their tails!

How a ‘jumping gene’ caused apes (and humans) to quit monkeying around and ditch their tails.

RNA interference was a knockout discovery in 1998!

RNA interference was a knockout discovery in 1998!

One of the best ways to figure out what a gene does is to get rid of it and see what happens.

Complete Genomics wants America to give them a second chance. Should they?

Paid-members only

Genomics Featured

Complete Genomics wants America to give them a second chance. Should they?

Sickle Cell Anemia was molecularly characterized in 1949 using a revolutionary new technique: electrophoresis

Sickle Cell Anemia was molecularly characterized in 1949 using a revolutionary new technique: electrophoresis

Sickle Cell Anemia was the first inherited disease to be molecularly characterized. It was done in 1949 using a revolutionary new method: electrophoresis.

The yeast used to brew Guinness is unlike any other found in Ireland or the UK

The yeast used to brew Guinness is unlike any other found in Ireland or the UK

The yeast used to make your most recent Guinness isn’t like any other found in Ireland or the UK!

80% of patients with an autoimmune disease are women, we are now beginning to understand why

80% of patients with an autoimmune disease are women, we are now beginning to understand why

Approximately 80% of people with autoimmune diseases are women. We may now understand why this extreme gender bias exists.

There was a lot of 'omics sizzle at this years' AGBT, and I'm not talking about the wicked sun-burns

Paid-members only

Conferenceomics Featured

There was a lot of 'omics sizzle at this years' AGBT, and I'm not talking about the wicked sun-burns

Genomics is better with friends **cough** transcriptomics, proteomics, metabolomics, and epigenomics **cough**

Genomics is better with friends cough transcriptomics, proteomics, metabolomics, and epigenomics cough

Spoiler Alert: The future of disease early detection isn't going to be genomics

The story of how Solexa and Illumina combined forces to revolutionize the field of genomics

The story of how Solexa and Illumina combined forces to revolutionize the field of genomics

Illumina is considered by many to have single handedly transformed the field of genomics. They did it by building on the foundation Solexa established in 1997.

Why magnetic beads are the most important reagent in genomics

Why magnetic beads are the most important reagent in genomics

Magnetic beads don't get much respect in the sequencing world, but they're hella useful. Here are some applications you should try!

A giant, million sample genetic database was released in November

A giant, million sample genetic database was released in November