Therapeutics How does the brain cause headaches if it can't feel pain? Do you suffer from migraines? We might have some new clues about how they happen.
Genomic Sequencing Counting the things short-reads are good for What's the point of short-reads if long-reads do basically everything in genomics better? There are five, FIVE, *thunderclap*, applications where short reads excel, ah, ah, ah!
Proteins Green Fluorescent Protein was first discovered in Jellyfish in 1960 In 1994, an obscure jellyfish protein was stuck into a worm. It has enlightened biology and medicine ever since.
Paid-members only Protein Sequencing There are a lot of companies working on protein sequencing, so who is in the lead?
Protein Sequencing Reverse Translation doesn't exist in nature, but that's not stopping us from trying to do it! There are few things deserving of the superlative ‘holy grail,’ but Reverse Translation is one of them.
Diagnostics Assay failures are common in the clinical lab, here are 5 of my favorites. Troubleshooting assay failures is a second full-time job in R&D. Here are my top 5 'favorite' root causes!
DNA The Lac Operon: Everyone's heard of it, but do you know how it was discovered? 'If gene expression determines the function of a cell, it must be important to control that process?' Yes, very! Let me tell you about the PaJaMo experiment.
Diagnostics Parkinson's Disease gets a new risk factor A recent survey of 2,000 families with Parkinson’s Disease has turned up a new risk factor: a variant in RAB32
Genomic Sequencing Sequencing libraries and strategies for doing quality control You can't do sequencing without libraries. But you don't know if you have libraries unless you look at them.
Breakthroughs Defenders from the sea: Our bloody history with horseshoe crabs Horseshoe crab blood is our first line of defense against endotoxin contamination of surgical tools and medical devices. Seriously.
Paid-members only Omics One of the most underappreciated techniques in Omics is Hi-C. That needs to change
RNA Bridge RNAs are here to take CRISPR's crown Move over CRISPR, bridge RNAs are here to make the precision genome edits that you can't.
Fecal Matters The messiest part of Omics? Dealing with all the different sample types The good, the bad, the...uhhh: Everything you ever wanted to know about all the different Omics sample types!
High-Throughput Sequencing In 2009, high throughput sequencing gave us our first glimpse of the 3-D organization of the DNA in our nuclei While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn.
Evolution Why do women live longer than men? Sperm production is expensive Are you a guy? Do you want to live longer? It might be time to ditch your sperm.
Genetics Genealogy databases aren't just for finding your relatives anymore The killer app for consumer genetics literally is to catch killers. Here's why:
Genetics The 'Histone Code' fundamentally changed how we think about gene expression Histones were once thought to just be dumb structural proteins that held chromatin together; now we know that the ‘histone code’ is a major regulator of gene expression.
