Paid-members only Illumina Featured Add open-source sequencers to the list of things short-read manufacturers have to deal with now
DNA The discovery of the DNA double-helix was the culmination of decades of work from numerous contributors History is written by victors, and that statement couldn't be more true than it is in the case of Watson and Crick's 'discovery' of the DNA double helix.
Proteomics There are lot's of cool new ways to measure the proteome! High throughput proteomics could revolutionize our understanding of human disease, but it's going to take some major innovations to get us there!
Proteomics Proteomics based MCEDs are coming in hot and will probably hit the market sooner than anyone thinks Proteomics is coming to the oncology market faster than any of you think. This paper shows why.
DNA Linus Pauling proposed a triple helical structure for DNA in 1953. Here's why he got it so wrong The kaleidoscopic image below is the triple helix Linus Pauling proposed as the structure of DNA in February 1953. Here's why he got it so wrong:
Proteomics The importance of taking out the trash: An overview of cellular protein degradation pathways The importance of taking out the trash: An overview of cellular protein degradation pathways.
Virology The evidence that Epstein-Barr Virus can cause multiple sclerosis is mounting It has been hypothesized that infection with Epstein-Barr Virus can result in the development of multiple sclerosis. We now have good evidence that this is true.
DNA Did you know that there was a high quality diffraction of B-DNA made a year before Rosalind Franklin and Raymond Gosling generated photo 51? Elwyn Beighton and William Astbury generated a nearly flawless diffraction of B-DNA in 1951, a full year ahead of Franklin and Gosling. They never shared or published it.
Proteomics The Proteome: It's a bit more complex than any of us would like Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA.
Protein Sequencing Sequencing proteins with nanopores is hard. Engineered nanopores might make it a little easier. Nanopores, what can't they do? Well, they're not very good at sequencing proteins. Yet.
Paid-members only Start-Upomics Featured RavGen got Natera to cough up $57m. What's going on with non-invasive screening test IP?
DNA Florence Bell and William Astbury's x-ray diffraction work on a 'pile of pennies' The first crystal structure of DNA was published in 1938. It was generated by Florence Bell, a scientist you need to know.
Proteomics The Proteome: It's a bit more complex than any of us would like Proteoforms: This is where things start to get complicated.
Epigenomics The epigenome's role in aging gets some mechanistic answers Feeling old? It might be time to blame your epigenome.
Paid-members only Conferenceomics Featured A round-up of everything omics that happened at the JP Morgan Healthcare Conference
DNA The story of Phoebus Levene, one of the mostly invisible grandfathers of nucleic acids Watson and Crick were the first to describe the structure of the DNA double helix. Their major contribution to science was, at its core, a synthesis of all of the best data available at the time.
Proteomics The Proteome: what it is and why protein structure is so important The Proteome: we can’t live without it, but, what actually is it?
DNA Pfizer developed a technique for determining the primary structure of their mRNA vaccine including detecting base modifications, the 5'-cap, and the poly-A tail Pfizer developed a new method to determine the primary structure of RNA. 'So, they made a sequencer?' Kinda.
Paid-members only Start-Upomics Featured 23andMe has been in the news recently about a data breach, raising important questions about data security in the age of genomics
