Brian Krueger

Proteomics

The Proteome: It's a bit more complex than any of us would like

Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA.

Protein Sequencing

Sequencing proteins with nanopores is hard. Engineered nanopores might make it a little easier.

Nanopores, what can't they do? Well, they're not very good at sequencing proteins. Yet.

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Start-Upomics Featured

RavGen got Natera to cough up $57m. What's going on with non-invasive screening test IP?

DNA

Florence Bell and William Astbury's x-ray diffraction work on a 'pile of pennies'

The first crystal structure of DNA was published in 1938. It was generated by Florence Bell, a scientist you need to know.

Proteomics

The Proteome: It's a bit more complex than any of us would like

Proteoforms: This is where things start to get complicated.

Epigenomics

The epigenome's role in aging gets some mechanistic answers

Feeling old? It might be time to blame your epigenome.

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Conferenceomics Featured

A round-up of everything omics that happened at the JP Morgan Healthcare Conference

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January 14, 2024 Hey There! Thanks for spending part of your Sunday with Omicly! This week's headlines include: 1) The epigenome's role in aging gets some mechanistic answers 2) The Proteome: It's a bit more complex than any of us would like 3) Florence

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Weekly Reading List

Weekly Reading List Jan 14, 2024

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Weekly Reading List

Weekly Reading List: Jan 7, 2024

DNA

The story of Phoebus Levene, one of the mostly invisible grandfathers of nucleic acids

Watson and Crick were the first to describe the structure of the DNA double helix. Their major contribution to science was, at its core, a synthesis of all of the best data available at the time.

Proteomics

The Proteome: what it is and why protein structure is so important

The Proteome: we can’t live without it, but, what actually is it?

DNA

Pfizer developed a technique for determining the primary structure of their mRNA vaccine including detecting base modifications, the 5'-cap, and the poly-A tail

Pfizer developed a new method to determine the primary structure of RNA. 'So, they made a sequencer?' Kinda.

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Start-Upomics Featured

23andMe has been in the news recently about a data breach, raising important questions about data security in the age of genomics

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January 7, 2024 Hey There! Thanks for spending part of your Sunday with Omicly! This week's headlines include: 1) Pfizer developed a technique for determining the primary structure of their mRNA vaccine including detecting base modifications, the 5'-cap, and the poly-A tail! 2) The Proteome: what

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Proteomics Featured

It was a bad week for plasma proteomics darlings Olink and SomaLogic

DNA

The story of the polymerase chain reaction and how sometimes timing is everything

The method below has been cited more than 600,000 times and is one of the most important developments in the history of science.

Transcriptomics

Single-Cell and Spatial Transcriptomics and why they’ve gotten so much attention recently

Everything you need to know about the status quo and new kid on the block.

Genomics

Genomics is better with friends **cough** transcriptomics, proteomics, metabolomics, and epigenomics **cough**

Spoiler Alert: The future of disease early detection isn't going to be genomics

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Weekly Reading List

Weekly Reading List: Dec 31, 2023

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