Transcriptomics STAMP brings us non-destructive single-cell profiling without the sequencing No sequencer needed: Imaging based single-cell multiomics
Genetics Loss of Y could be helping to make tumors in men more aggressive Who needs a Y chromosome anyway? Losing it could be making tumors in men more aggressive
Proteins Amino acids? We don't need more stinking amino acids...or do we? Genetic code expansion might be the coolest thing in Omics that you've never heard of.
DNA Linus Pauling got the 3D structure of DNA wrong The kaleidoscopic image below is the triple helix Linus Pauling proposed as the structure of DNA in February 1953. Here's why he got it so wrong:
Weekly Reading List Weekly Reading List: June, 23 2025 Gene therapy faces fresh uncertainty as two more top FDA officials departThe reported dismissal of high-ranking CBER officials Nicole Verdun and Rachael Anatol resurfaced lingering concerns about how gene therapies will be regulated under new FDA leadership.BioPharma DiveBen FidlerFDA blocks new clinical trials that ship cells from US to
CRISPR CRISPR-Associated Transposases (CASTs) make large DNA insertions in Human cells a reality Tired of only being able to use CRISPR to make small edits? CASTs are here to change that!
Proteomics The basics of Proteasomes, Lysosomes, and the therapeutics that can target them! PROTACs and LYTACs: How therapeutics can take advantage of proteomic garbage men.
DNA A DNA diffraction pattern that was lost to history Elwyn Beighton and William Astbury generated a nearly flawless diffraction of B-DNA in 1951, a full year ahead of Franklin and Gosling. They never shared or published it.
Weekly Reading List Weekly Reading List: June 16, 2025 Time for Congress to save American science … and the nationWe believe the best hope for saving science and, perhaps, saving our form of democracy, is convincing at least a couple dozen Republican members of Congress that it’s up to them—that the stakes require exercising the prerogatives of the
Microbiology Real-Time monitoring of hospital pathogens pays dividends Hospital genomic surveillance of pathogens stops outbreaks, prevents deaths and saves a bunch of money.
Oncology Structural variant based MRD testing is coming to an oncologist near you Structural Variants: What are they good for? MRD testing, actually.
DNA A Pile of Pennies The first 3D structure of DNA was published in 1938. It was generated by Florence Bell, a scientist you need to know.
Weekly Reading List Weekly Reading List: June 9, 2025 Scientists worry about possible publishing banHHS secretary Kennedy says the US might launch alternatives to leading medical journalsAmerican Chemical SocietyDalmeet Singh Chawla, special to C&ENEfficient mRNA delivery to resting T cells to reverse HIV latency - Nature CommunicationsResting T cells are difficult to manipulate, and are a reservoir
Genomics The genetics of pregnancy loss 10-20% of pregnancies end in miscarriage. Genetics is helping us to explain why that is!
DNA The 2D structure of DNA was solved by someone you've probably never heard of before Watson and Crick were the first to describe the structure of the DNA double helix. Their major contribution to science was, at its core, a synthesis of all of the best data available at the time.
Weekly Reading List Weekly Reading List: June 2, 2025 Rare ‘ambidextrous’ protein breaks rules of handednessMost proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms.NatureEwen CallawayEuropean Sperm Donor Passes on Cancer Predisposition Variant to at Least 23 ChildrenA donor to a European sperm bank has transmitted a likely pathogenic variant for
CRISPR CRISPR cures a metabolic disorder in an infant's liver Will personalized gene-editing therapies become the standard of care for ultra-rare diseases?
Proteomics Feeling like the dog that caught a car now that you have all this proteomic data? So, once we have all of this amazing proteomic data, what do we do with it???
Molecular Biology PCR has a more interesting history than you might have been told The method below has been cited more than 600,000 times and is one of the most important developments in the history of science.
Weekly Reading List Weekly Reading List: May 26, 2025 Covid 2020: An intimate look at health worker’s lives amid a global crisisTheatre nurse David Collyer wanted to shoot a documentary photography project in the last years of the Welsh hospital he worked in. Then Covid-19 appeared.BBCStephen DowlingIn its flagship journal, the CDC keeps publishing papers after firing
Genetics A gene for short sleep duration Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep!
Proteomics Structure equals function might be the most important phrase in proteomics Proteomics: It’s all about the structures!
NIPT Non-invasive prenatal testing is a big business. Here's how it got its start. The two gels below spawned a multi-billion dollar industry that didn't exist prior to their publication in 1997.
