Paid-members only High-Throughput Sequencing What was buzzing at AGBT? Spatial, $80 Genomes, and Roche SBX
Neuroscience New genes and pathways have been discovered in bipolar disorder 60-80% of people with bipolar disorder (BD) inherited it from a family member, but the genetic causes of BD are largely unknown.
Genomic Mapping How genomic mapping finally helped to "complete" the human genome, kinda Did you know the human genome wasn't actually completed until 2022? No, seriously!
Proteins The structure of tRNA won a Nobel, the person who figured it out, didn't The next great mystery to solve after the discovery of the DNA double helix was to figure out how the nucleotide sequence coded for proteins.
Artificial Intelligence AI is making new, functional, enzymes now Artificial intelligence has been used to develop a new enzyme that can catalyze a multistep chemical reaction!
Molecular Biology Magnetic beads might be the most useful reagent in genomics Magnetic beads don't get much respect in the sequencing world, but they're hella useful. Here are some applications you should try!
Diagnostics Early pregnancy tests were wild For the better part of 40 years, pregnancy tests were done by injecting urine into animals and seeing what happened. No, seriously!
Weekly Reading List Weekly Reading List: Feb 24, 2025 Roche Announces SBX Technology, Creates Sequencing BuzzRoche introduces Sequencing by Expansion (SBX) technology in a webinar just a few days before the AGBT meeting takes place in Florida.GEN - Genetic Engineering and Biotechnology NewsJulianna LeMieux, PhDSequencing by Expansion SBX | Nanopore sequencingSequencing by expansion (SBX) offers a new paradigm in
Oncology MRD Testing: It's just a phase All of the variants are getting in on MRD testing, even the phased ones!
Structural Variants Karyotypes? FISH? Arrays? What is this, the 20th century??? Genomic mapping: bringing cytogenetics into the 21st century
Genomics Telomerase and how linear genomes attempt to stay long What if I told you that the ends of our chromosomes are a paradox and we didn't fully understand how human DNA was copied until 1989?
Paid-members only Spatial In a win for scientific innovation, Parse succeeds in invalidating 10x’s single-cell patents
Policy Indirects, what are they good for? Do we seriously need to have a conversation about why indirects are important? Really?!
Genomics Rare diseases get a second opinion and new diagnoses A re-analysis of rare disease patients' genetic data delivers 500 new diagnoses
Oncology FFPE Sucks. Formalin-fixed, paraffin-embedded (FFPE) tissues in oncology diagnostics: is there a better way?
Epigenetics The discovery that X-inactivation is caused by a long non-coding RNA Biologically female mammals have two X chromosomes, but what might surprise you is that one of those X's is turned off.
Paid-members only High-Throughput Sequencing Roche finally has something to say about what they've been doing for the past 10 years with Genia and Stratos Genomics
Oncology Watch out, Structural Variants are coming to MRD testing! SNPs better watch their back, a new variant class is looking to steal the MRD limelight
Molecular Biology The isolation of insulin required a lot of trial and error Insulin: It was believed to exist, but everyone who tried to isolate it failed.
