Immune System Our skin has it's own distinct immune system Our immune system plays a critical role in recognizing, fighting, and preventing infections, but now we’ve discovered that our skin has its own!
Microbiomics Expert panel on clinical microbiome use: "More evidence needed" An international panel says clinical microbiomes aren't ready for primetime...yet
Epigenetics There are lots of tools for probing the epigenome If epigenetics is the study of modifications that aren't coded in the DNA, how can we use DNA sequencing to learn anything about the epigenome?
High-Throughput Sequencing Automated sanger sequencing's fluorescent beginnings We ‘completed’ the human genome in 2003, thanks mostly to commercial industrial engineering.
Paid-members only Regulations HOT TAKE: With lawsuits percolating in the background, CAP, Congress and others start working on VALID 2.0
Artificial Intelligence Foundation models are all the rage today - Now there's one for genomes! EvoAI: a genome foundation model for building prokaryotes
Epigenetics Epigenetics! You've heard of it, but what do you know about it? There are lots of ‘omes: There's the genome, transcriptome, proteome, and metabolome - but the one above them all is the epigenome.
Cloning Dolly the sheep stole our hearts in 1997 6LL3, better known as Dolly the sheep, showed that mammalian cloning was possible in 1997.
Paid-members only FDA Just when you thought you might be safe, FDA sticks its nose into MRD testing (again)
Artificial Intelligence RhoFold+: A large language model for RNA structure prediction Can LLMs predict RNA structures?
RNA Direct RNA sequencing might tell us about more than just the bases Post-transcriptional modifications: Why sequencing RNA directly is the future of transcriptomics
Historical Paper Review Oswald Avery, Colin Macleod and Maclyn McCarty showed that DNA was the genetic material in 1944 One of the most important papers in the history of genetics was basically ignored when it was published in 1944.
Paid-members only How might the election change how FDA approaches enforcement of their new LDT rule?
Diagnostics Metagenomics hits the clinic to diagnose CNS infections Whole genome metagenomics is better than the standard of care in detecting the causal bugs of CNS infections
Transcriptomics Transcriptomics is better with long-reads Spoiler Alert: The holy grail of transcriptomics is long-reads.
Molecular Biology Molecular Biology is the offspring of biochemistry and genetics The field of molecular biology was born in 1941 through the marriage of genetics and biochemistry.
Nanopores Nanopores are getting on the rapid NICU/PICU sequencing bandwagon Nanopores take on rapid neonatal sequencing
Transcriptomics New tech always has risks and limitations, single-cell and spatial transcriptomics are no exception Single-Cell and Spatial Transcriptomics: Risks, Limitations, and Questions to Ask
Historical Paper Review A wormy discovery becomes a knockout laboratory technique One of the best ways to figure out what a gene does is to get rid of it and see what happens.
