Nanopores Will nanopores enable single molecule protein sequencers? Brain storming about nanopore based protein sequencing generates new hypotheses to test
Molecular Biology In silico identification of a side effect free weight loss peptide The quest to find better tolerated weight loss drugs is well on its way and computational drug discovery has already identified at least one promising candidate!
Proteomics The proteome is so hot right now The Proteome: we can’t live without it, but, what actually is it?
Epigenetics Hi-C showed us that the genome has topology While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn.
Paid-members only High-Throughput Sequencing Turnabout is fair play as Illumina gets caught up in a trade war kerfuffle
CRISPR The creation of the (adorable) Woolly Mouse-mmoth! Colossal Biosciences makes a mini-mammoth mouse using multiplex gene editing
Genomics Just because it's in your genes, doesn't mean it's your fate One thing we constantly battle in genomics is, “What does it all mean?”
Epigenetics The formulation of the histone code forever changed our view of the genome Histones were once thought to just be dumb structural proteins that held chromatin together; now we know that the ‘histone code’ is a major regulator of gene expression.
Paid-members only Proteomics Will Nautilus Biotechnology ever release their proteome fingerprinting product?
Population Genetics When a "rare variant" isn't actually rare A lack of genetic database diversity highlights red herrings in disease diagnosis
Genetics Genetic discrimination is still alive and well in the US Did you know that before 2008, insurers could discriminate against you based on your genetic risk for disease?
Vaccines mRNA vaccines almost didn't happen It is estimated that COVID-19 vaccination has prevented over 20 million deaths worldwide. We can thank the dogged perseverance of a browbeaten scientist for that.
Paid-members only High-Throughput Sequencing What was buzzing at AGBT? Spatial, $80 Genomes, and Roche SBX
Neuroscience New genes and pathways have been discovered in bipolar disorder 60-80% of people with bipolar disorder (BD) inherited it from a family member, but the genetic causes of BD are largely unknown.
Genomic Mapping How genomic mapping finally helped to "complete" the human genome, kinda Did you know the human genome wasn't actually completed until 2022? No, seriously!
Proteins The structure of tRNA won a Nobel, the person who figured it out, didn't The next great mystery to solve after the discovery of the DNA double helix was to figure out how the nucleotide sequence coded for proteins.
Artificial Intelligence AI is making new, functional, enzymes now Artificial intelligence has been used to develop a new enzyme that can catalyze a multistep chemical reaction!
Molecular Biology Magnetic beads might be the most useful reagent in genomics Magnetic beads don't get much respect in the sequencing world, but they're hella useful. Here are some applications you should try!
Diagnostics Early pregnancy tests were wild For the better part of 40 years, pregnancy tests were done by injecting urine into animals and seeing what happened. No, seriously!
